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   Table of Contents - Current issue
Coverpage
January-March 2022
Volume 5 | Issue 1
Page Nos. 1-30

Online since Tuesday, March 22, 2022

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ORIGINAL ARTICLES  

Application of nonsteroidal anti-inflammatory drugs in aortic aneurysm p. 1
Rubén T Moro Rodríguez, Daylin Ricardo Olivera, Jose Luis Valdes Cantero, Vielka Gonzalez Ferrer
DOI:10.4103/2589-9686.340412  
INTRODUCTION: Aortic aneurysms have among their main factor for rupture, growth, produced by the weakening of the aneurysmal wall influenced by different risk factors. MATERIAL AND METHOD: A 5-year investigation was carried out with a group of 63 patients with aortic aneurysms who, for different reasons, were not operated on during the study period. They were divided into two groups, one called a study with 48 patients and another with 15 who use in the study group, ibuprofen-based medical treatment (non-steroidal anti-inflammatory drugs [NSAIDs) in doses of 800 mg per day and sixmonthly ultrasound controls throughout the period of the investigation, measuring the aneurysmal diameters to demonstrate the growth, detection or reduction of the same. RESULTS: The usefulness and efficacy of the use of NSAIDs in the field of medical treatment of aortic aneurysms was demonstrated, since during the investigation of the two study groups, we achieved higher survival rates for the group treated with NSAIDs. CONCLUSIONS: Through growth control as the main rupture factor and therefore a complication that in most cases is fatal, we achieved a reduction in the aneurysmal diameter in a number of patients with higher survival rates than in the control group. Graphs up to 5 years are presented that support the results achieved.
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Molecular mechanism of Si-Miao-Yong-An decoction in the treatment of diabetic foot microcirculation and network pharmacology information analysis results p. 10
Zhao Wei, Dong Mingyang, Pan Dikang, An Yanbo, Tong Le, Yang Zhongkai, Zhang Jing, Lv Bonan, Shi Xiaoming
DOI:10.4103/2589-9686.340414  
OBJECTIVE: This study aims to explore the effect and mechanism of Si-Miao-Yong-An decoction (SMYAD) on diabetic foot by simulating the microenvironment of diabetic foot in vitro, and further verify these results using bioinformatics analysis technology, in order to provide a basis for the treatment of diabetic foot with traditional Chinese medicine. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were cultured under hypoxia to simulate the microcirculation of diabetic foot. Then, these were administered with SMYAD for intervention. Afterward, the cell viability was detected by MTT assay, the apoptosis was detected by flow cytometry, and the STAT3 signaling pathway and Bcl-2 and Bax protein expression were detected by Western blot. Next, TCMSP was used to determine the chemical composition and target gene information of the SMYAD, and the GeneCards database was used to search for the disease-related target gene information of diabetic foot. Furthermore, the Venny 2.1 online software was used to screen and obtain the drug–disease common target genes for the SMYAD and diabetic foot. The common target genes were entered into the STRING database for retrieval, in order to construct the network diagram for protein-related action, and the R software was used to analyze the pathway enrichment, in order to explore the mechanism of the SMYAD in the treatment of diabetic foot microcirculation. RESULTS: Compared with the control group, the SMYAD increased the activity of HUVECs cultured in the hypoxia state but decreased the apoptosis rate. Furthermore, the protein expression of p-STAT3 and Bcl-2 increased, and the protein expression of Bax decreased (P < 0.05). A total of 235 drug-related target genes were found by screening, and 4553 target genes related to diabetic foot were obtained. The Venny software analysis revealed that there were 171 drug–disease interaction target genes. The STRING database and the GO and KEGG functional enrichment analysis revealed that STAT3, AKT, MAPK, and other proteins were involved, and that these may be correlated to the mechanism of the SMYAD in the treatment of diabetic foot microcirculation. CONCLUSION: SMYAD can affect the expression of Bcl-2 and Bax genes by regulating the activity of the STAT3 signaling pathway, playing a role in the treatment of diabetic foot.
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AccuVein® fails to facilitate venous marking for saphenous veins harvesting in untrained students p. 18
Pierre Ramondou, Alessandra Bura-Rivière, Wassim Mokaddem, Jeanne Hersan, Charlotte Josse, Pierre Abraham, Olivier Fouquet, Jean-Pierre Bossavy, Francois-Xavier Lapebie, Samir Henni
DOI:10.4103/2589-9686.340416  
CONTEXT: Ultrasound marking of saphenous veins before vein harvesting facilitates the surgical procedure but is time-consuming. AIM: We evaluated the time benefit of saphenous veins marking by the AccuVein® AV400 system (AccuVein Inc., NY, USA) coupled with ultrasound, over ultrasound alone. SETTINGS AND DESIGN: Multi-center open-label randomized interventional study in two parallel groups. SUBJECTS AND METHODS: After randomization, saphenous veins markings were performed using either AccuVein® coupled with ultrasound or ultrasound alone. One-leg marking time, vascular physician postexamination satisfaction rating, and number of single-use felt markers used were recorded. STATISTICAL ANALYSES: The continuous variables were compared using the Fisher test, whereas Likert scale scores were compared using the nonparametric Mann−Whitney test. The learning effect was evaluated by linear and nonlinear regression models. RESULTS: The average duration of saphenous veins marking (459 ± 184 vs 555 ± 226 s, P = 0.116) and the number of felt markers used were not significantly different between the two techniques. Vascular physician satisfaction was significantly lower with than without the AccuVein® associated to ultrasound. CONCLUSIONS: AccuVein® examination coupled with ultrasound as part of the marking process does not provide a significant benefit in terms of time, satisfaction, or need for markers.
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REVIEW ARTICLE Top

Clinical improvement after stenting for chronic iliofemoral venous obstruction: A review of large studies p. 22
Arjun Jayaraj, Seshadri Raju
DOI:10.4103/2589-9686.340413  
A review of large studies where patients underwent stenting for symptomatic chronic iliofemoral venous obstruction (CIVO) and had validated clinical and/or quality of life metrics with a follow-up of at least 12 months was performed. Such studies were identified through searches of the MEDLINE and Embase databases in addition to a search of the Cochrane Central Register of Controlled Trials using appropriate search terms. These studies demonstrated that venous stenting is a durable intervention that confers clinical and quality of life improvement in patients with symptomatic CIVO who have failed conservative therapy. While significant improvement is common, complete resolution is rare, and in such patients, consideration should be given to treatment of other concomitant diagnoses including deep venous reflux, lymphedema, and chronic compartment syndrome.
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CASE REPORT Top

Brachial aneurysm caused by a long-term axillary crutch - A case and literature review p. 28
Pin Ye, Yunfei Chen, Yiqing Li, Yongquan Gu, Chuanqi Cai, Ping Lü
DOI:10.4103/2589-9686.340415  
Brachial aneurysms are a rare disease, accounting for 0.5% of peripheral aneurysms. Using a long-term axillary crutch may be associated with arterial injury and induce upper extremity aneurysm formation. A 67-year-old woman had a history of using a long-term underarm crutch due to polio disease. Physical examination revealed edema of the left upper limb, pulseless of the brachial artery, and disappearance of distal radial pulse. The imaging examination revealed a brachial arterial aneurysm in the left upper limb, along with thrombosis. The aneurysm and mural thrombus were excised. The great saphenous vein graft was inserted to reconstruct occluded artery blood supply; the left brachial and radial arteries pulsed well after operation. This case report suggests that long-term use of axillary support for patients should be done with caution. Regular follow-up of upper extremity vascular morphology should be done. Timely anticoagulant therapy to prevent thrombosis and surgical resection of aneurysms are effective strategies for resolving complications.
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